Pluto Bioinformatics

GSE76523: Methylomes and Transcriptomes of Human Pluripotent-to-Cardiomyocyte Differentiation [RNA-seq]

Bulk RNA sequencing

In this report, Tompkins et al describe the derivation, differentiation stage-specific purification, and genome-wide analysis of cardiomyocytes derived from hESCs. Key features of the molecular programs that define human cardiac muscle cell differentiation were described and researchers observed that cells may harbor epigenetic DNA methylation memories that reflect the gene activation history of important developmental genes. SOURCE: Joshua Tompkins (jtompkins@coh.org) - City of Hope