We studied the role of the histone methyltransferase DOT1L in B cell development and differentiation. Here we generated RNA-seq data naive B cells from (WT) MB1+/-;Dot1L+/+ and Dot1L KO (MB1+/-;Dot1Lfl/fl) mice. This data was to define tissue specific expression signatures and it was compared with H3K79me2 ChIP-seq data from the same subsets. SOURCE: Fred van Leeuwen (fred.v.leeuwen@nki.nl) -  Netherlands Cancer Institute

Pluto Bioinformatics

GSE138909: Transcriptional profiling of nave and in vitro activated B cells from WT and DOT1L KO mice