Pluto Bioinformatics

GSE76367: METTL3 promotes translation in human cancer cells

Bulk RNA sequencing

we find METTL3 associates with polyribosomes and promotes translation. METTL3 depletion inhibits translation, and both wild-type and catalytically inactive METTL3 promote translation when tethered to the 3' untranslated region (UTR) of a reporter mRNA. Mechanistically, METTL3 enhances mRNA translation through an interaction with the translation initiation machinery. SOURCE: Peng Du (Peng.Du@childrens.harvard.edu) - Richard Gregory Boston Children’s Hospital, Harvard Medical School