Pluto Bioinformatics

GSE90684: IGF2BP proteins Enhance mRNA stability

Bulk RNA sequencing

To evaluate the effect of IGF2BPs on mRNA stability and gene expression output, we conducted RNA-seq in individual IGF2BP knockdown and control HepG2 cells with or without actinomycin D treatment. Our RNA-seq and RNA stability profiling revealed that IGF2BPs were involved in RNA stability regulation and contributed to the stabilization of the transcriptome. SOURCE: Jianjun Chen (jianchen@coh.org) - Chen Lab City of Hope