Pluto Bioinformatics

GSE126749: GEF-H1-IRF5 mediated gene expression changes in BMDM by MDP recognition

Bulk RNA sequencing

The transcription factor IRF5 is essential for immune defense against pathogens. Here, the authors show that the microtubule-associated factor GEF-H1 plays a critical role in host defense against Listeria monocytogenes in macrophages via activation of the IRF5 kinase IKKe SOURCE: Hans-Christian Reinecker (hans-christian_reinecker@hms.harvard.edu) - Reinecker Lab Massachusetts General Hospital