Pluto Bioinformatics

GSE84577: Integrated analyses identify phenotype specific BMP4 signaling in breast cancer [RNA-seq]

Bulk RNA sequencing

Bone morphogenetic protein 4 (BMP4) plays an important role in cancer pathogenesis. In breast cancer, it reduces proliferation and increases migration in a cell line-dependent manner. To characterize the transcriptional mediators of these phenotypes, we performed RNA-seq and DNase-seq analyses after BMP4 treatment in MDA-MB-231 and T-47D breast cancer cells that respond to BMP4 with enhanced migration and decreased cell growth, respectively. SOURCE: Tommi,Tapani,Rantapero (tommi.rantapero@staff.uta.fi) - University of Tampere