Pluto Bioinformatics

GSE146629: Role of Rnf40-dependent histone monoubiquitination in peripheral nervous system myelination [RNA-Seq]

Bulk RNA sequencing

To address the role of monoubiquitination of histone H2B at lysine 120 (H2Bub1), we inactivated the responsible E3 ligase by deleting Rnf40 in developing Schwann cells. Rnf40 becomes important for proper Schwann cell development shortly before and during differentiation. Its absence in Schwann cells leads to a peripheral neuropathy. RNA-Seq studies were performed on sciatic nerves from control mice and mice with a Schwann cell-specific deletion of Rnf40 to analyze changes in gene expression. These revealed substantial changes in the expression of genes associated with myelination, lipid metabolism and cell adhesion. SOURCE: Michael WegnerMichael Wegner Friedrich-Alexander Universität Erlangen-Nürnberg