We report two clusters in the overall profiles of expression among the samples. At the parasitemia onset, there is a strong interferon response reflected in up-regulation of co-regulated transcripts, while unexpectedly we also see down-regulation of transcripts related to TLR signaling and innate immunity. RNASeq also suggested differential expression of reticulocytes and a subset of T cell function. No obvious difference in the transcriptomes of nave and semi-immune volunteers was seen, however several hundred genes were up-regulated in nave individuals. SOURCE: Monica,L.,Rojas-Peña (monica.rojas@gatech.edu) - Center for Integrative Genomics (CIG) Georgia Institute of Technology

Pluto Bioinformatics

GSE67184: Transcription Profiling of Malaria-Nave and Semi-Immune Colombian Volunteers in a Plasmodium vivax Sporozoite Challenge [RNA-Seq]