Pluto Bioinformatics

GSE67128: Comparative whole-transcriptomic analysis between normal and AKAP-Lbc-depleted human embryonic stem cells

Bulk RNA sequencing

Human embryonic stem cells (hESCs) have the unique property of immortality, ability to infinitely self-renew and survive in vitro. In contrast to tumor-deribed cells, their immortality are free from any genomic abberations. Instead, they depend on the AKAP-Lbc/Rho signaling cascade. To understand the downstream way, we performed RNA-seq analyses between normal and AKAP-Lbc-depleted hESCs using the doxycyclin-inducible gene silensing strategy. SOURCE: Masatoshi Ohgushi (mohgushi@cdb.riken.jp) - Laboratory for Organogenesis and Neurogenesis RIKEN Center for Developmental Biology