Pluto Bioinformatics

GSE134408: Transcriptome analysis of naive B cells from CD19Cre and CD19Cre_STAT6vt mice

Bulk RNA sequencing

To investigate how activated STAT6 modulates B cells development and function in vivo, we characterized mice that express a constitutively active version specifically in B cells. CD19Cre_STAT6vt mice show spontaneous phosphorylation and nuclear translocation of STAT6 in B cells. Based on the finding that STAT6vt accumulates in the nucleus of nave splenic B cells in CD19Cre_STAT6vt mice, we next determined the changes of the global transcriptome by RNAseq analysis. SOURCE: David Voehringer (david.voehringer@uk-erlangen.de) - University Clinic Erlangen