Purpose:Next-generation sequencing (NGS) were performed to investigate the differentially expressed molecular signature that were associated with HBV-mediated liver fibrosis;	Method: four cDNA libraries of separated groups ranging from 1, 3, 6-months post injection were constructed in the HBV (-) and analyzed using RNA-seq.;	results: Sequencing of the clean reads resulted in ~2940 million reads per sample, for a total of ~438 million reads across 12 samples.  Specifically, an average of 16,782, 17,088, 18,701, and 19,364 genes were identified  in the HBV (+) mouse (1, 3, 6-months post injection) and HBV (-) mouse (control groups), respectively. SOURCE: Fangming Kan (kfm86@163.com) -  MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences

Pluto Bioinformatics

GSE95424: Transcriptome analysis of liver tissue in HBV - associated liver fibrosis mice