Pluto Bioinformatics

GSE141737: SOAT1 knock-out downregulates the expression of mevalonate pathway genes in PDAC organoids

Bulk RNA sequencing

One of the emerging cancer vulnerabilities is altered metabolism, and several metabolic pathways have been shown to promote pancreatic ductal adenocarcinoma (PDAC). Here we use genetic targeting to delete SOAT1 from murine PDAC metastasis organoids, and use RNA-seq to identify genes differentially regulated in normal and cholesterol-supplemented media conditions in the presence or absence of SOAT1. SOURCE: David,A.,TuvesonThe Tuveson Laboratory Cold Spring Harbor Laboratory