Pluto Bioinformatics

GSE66557: Transcriptome analyses of skeletal muscle in B-crystallin/HspB2 knockout and wild-type mice on a normal or high fat diet

Bulk RNA sequencing

We profiled the skeletal muscle transcriptome between wild type and B-crystallin/HspB2 knock mice exposed to normal chow and high fat diets to examine the role of B-crystallin/HspB2 in diet induced obesity. Combined with metabolic profiling of the mice, these data reveal that B-crystallin/HspB2 is involved in the genesis of insulin resistance on a high fat diet, and we provide extensive RNA profiling to illuminate potential mechanistic insights into the muscle-specific role of B-crystallin/HspB2. SOURCE: Daniel Toft (djtoft@northwestern.edu) - Northwestern University