Pluto Bioinformatics

GSE141725: Early removal of senescent cells protects retinal ganglion cells loss in experimental ocular hypertension

Bulk RNA sequencing

Experimental ocular hypertension (IOP) induces senescence of retinal ganglion cells (RGCs) that mimicks events occurring in human glaucoma. An established transgenic p16-3MR mouse model in which the systemic administration of the small molecule ganciclovir (GCV) selectively kills p16INK4a-expressing cells was used to compare transcriptomes of retinas from IOP and control eyes in GCV-treated and non-treated mice, to investigate how experimental removal of senescent p16INK4a-positive cells impacts retinal cells in conditions resembling glaucoma. SOURCE: Michal Krawczyk (mikrawczyk@gmail.com) - UCSD