Pluto Bioinformatics

GSE153368: YB-1 inhibits proliferation of mesothelioma cells through multiple mechanisms

Bulk RNA sequencing

Here we utilized an unbiased whole RNA-seq approach to characterize the transcriptional effects of YB-1 knockdown in three mesothelioma cell lines (MSTO, VMC23 and REN cells). Bioinformatic analysis showed that YB-1 knockdown regulated 150 common genes enriched for mitotic genes, integrins and extracellular matrix. However, each cell line also displayed a unique transcriptional signature, with differential deregulation of cell death, the cell cycle, and p53 signaling observed across the three cell lines. SOURCE: Kaitao Lai (kaitao.lai@sydney.edu.au) - Neuroscience Anzac Research Institute, The University Of Sydney