Pluto Bioinformatics

GSE122742: Bulk RNA sequencing of intracortically-projecting neurons at P10

Bulk RNA sequencing

Distinct subtypes of intracortically-projecting neurons (ICPN) are present in all layers, allowing propagation of information within and across cortical columns. How the molecular identities of ICPN relate to their defining anatomical and functional properties is unknown. Here we show that the transcriptional identities of ICPN primarily reflect their broad axonal projections rather than their date of birth or laminar position. Thus, conserved circuit-related transcriptional programs are at play across cortical layers, which may preserve canonical circuit features across development. SOURCE: Denis Jabaudon (denis.jabaudon@unige.ch) - University of Geneva