Pluto Bioinformatics

GSE121768: Transcriptomics and chromatin accessibility analysis of MLL-AF9 early responses in mouse bone marrow cells

Bulk RNA sequencing

We investigated early changes of gene expressions and chromatin accessibilities in hematopoietic stem and progenitor cells (HSPCs) in response to MLL-AF9 oncogene expressions. Using RNA-Seq and ATAC-Seq, we analyzed HSPCs briefly exposed to MLL-AF9 for one or two days. Such analysis addressed the initial changes during malignant transformation, and provided insights into the primary functions of MLL-AF9 oncogene. SOURCE: Shangqin Guo (shangqin.guo@yale.edu) - Yale University