Pluto Bioinformatics

GSE155252: Mouse transcriptome of two genetic mutations of Grm1

Bulk RNA sequencing

We report two genetic mutations of GRM1, which are Grm1-S458A and Grm1b-R889W, identified from two natural short sleep families. The introduction of these mutations into mouse models also causes the mice to sleepless. Thus, these findings suggest GRM1 is another short sleep gene and highlight the essential roles of mGluRs in regulating human sleep. SOURCE: Zenghua Fan University of California, San Francisco

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