Purpose: The goals of this study are to compare the transcriptomic profile (mRNA-seq) of HD  and control patient iPSC-derived neural cells to identify alterations in gene expression;	Methods:  RNA were isolated from HD and control iPSC-derived neural cells. mRNAseq using Illumina Truseq mRNA PolyA+ v2 lib prep and Hiseq 2000. Statistical difference in mRNA levels were calculated with subsequent GO and pathway analysis;	Results: mRNAseq and statistical analysis revealed 1869 differentially expressed genes between HD and control iPSC-derived neural cells.;	Conclusions: Our study shows 1869 differentially expressed genes between HD and control iPSC-derived neural cells, and reveals gene networks that relevant to the mechanism of HD pathogenesis. SOURCE: Ryan,Gar-Lok,Lim (limrg@uci.edu) - Thompson UC Irvine

Pluto Bioinformatics

GSE95343: mRNAseq of Huntington's disease and control patient iPSC-derived neural cells