Pluto Bioinformatics

GSE65887: hnRNPK is involved in mRNA processing of a significant fraction of the transcriptome

Bulk RNA sequencing

Here, we report the first genomic-scale comprehensive characterization of mouse transcripts bound to hnRNPK. hnRNPK binding at the isoform level was evaluated via RNA-sequencing of liver samples obtained from obese and wild-type mouse models. The comparison of hnRNPK co-immunoprecipitated fractions with total RNA fractions in a given mouse model enabled quantitative evaluation of the binding affinity of hnRNPK for thousands of isoforms. SOURCE: Krzysztof Goryca Centrum Onkologii Instytut im. Marii Skłodowskiej Curie