Pluto Bioinformatics

GSE85422: Gene expression analysis of CD122HI versus CD122LO V7+ murine small intestinal IEL at 14-17 days of age

Bulk RNA sequencing

Background: The neonatal (D14-17) murine small intestinal epithelium is enriched for V7+ IEL displaying an immature CD122LO cell surface phenotype. We believe these cells are precursors for signature CD122HI V7+ IEL that predominate among small intestinal IEL from postnatal D21.; ; Method: To further characterise this potential precursor-product relationship, CD122hi Vg7+ and CD122lo Vg7+ IEL were purified from individual D14-D17 mice on four independent occasions and compared by total RNAseq.; ; Conclusion: ~3000 genes are differentially expressed between CD122HI and CD122LO murine Vg7+ neonatal IEL SOURCE: Rafael Di Marco Barros (r.barros@ucl.ac.uk) - Immunosurveillance Lab, Lincolns Inn Fields Laboratory Francis Crick Institute