The adult stem/progenitor cell maintenance in the prostate is regulated by a balance between BMP5 self-renewal signal and GATA3 dampening activity. Here we report that the transcription factor GATA3 controls basal stem/progenitor cell maintenance in the prostate by directly controling the expression of BMP5, a key effector of this activity. SOURCE: mathieu tremblay (mathieu.tremblay5@mcgill.ca) -  mcgill university

Pluto Bioinformatics

GSE155289: Gata3 controls stem/progenitor maintenance potential in prostate organoids