Pluto Bioinformatics

GSE139613: Post-translational regulation of the exon skipping machinery controls aberrant splicing in T cell leukemia [Patients I]

Bulk RNA sequencing

In this study, we show that pediatric T-cell acute lymphoblastic leukemia (T-ALL) has an alternative mechanism for aberrant splicing that involves post-translational regulation of the splicing machinery via deubiquitination. SOURCE: Yalu Zhou (yalu.zhou@northwestern.edu) - Ntziachristos Lab Northwestern University