Pluto Bioinformatics

GSE126345: Transcriptome analysis of different brain areas in Hcrt gene and Hcrt cell ablated mice

Bulk RNA sequencing

Hypocretin (HCRT) and melanin concentrating hormone (MCH) are brain neuropeptides regulating a wide range of functions including sleep and metabolism. Loss of function of HCRT causes the sleep disorder narcolepsy. We found that loss of HCRT neurons in Hcrt-ataxin-3 mice results in a specific 50% decrease in another orexigenic neuropeptide QRFP that might explain the metabolic syndrome in narcolepsy. SOURCE: Sylvain Pradervand (Sylvain.Pradervand@unil.ch) - DNA Array Facility UNI Lausanne