The analysis showed differences of transcriptomes between primary CDCs and immortalized CDCs as well as revealed TGF- inhibitor-SB431542 treatment induced expression changes. We identified hTERT immortalization could result the cell proliferation and cell cycle related genes upregulation in iCDC. KEGG results demonstrated that TGF- inhibitor SB431542 treatment could inhibit cardiomyopathy-related pathway which indicate TGF- signaling pathway may serve as new target for cardiomyopathy therapy, and iCDC could be used as a heart-related chemicals screening. SOURCE: zhenglong guo (13523257701@163.com) - tianjin-oxford gene therapy tianjin medical university

Pluto Bioinformatics

GSE131765: Establishment of hTERT immortalized mouse cardiosphere derived cell line