We show a strong correlation between PRMT1 substrates and complexes that are physically associated and linked to RNA metabolism. Transcriptome assays demonstrated that PRMT inhibition globally impaired RNA metabolism, including but not limited to RNA splicing, transcription termination, and R-loop formation. In addition, PRMTi caused a profound down-regulation of multiple pathways involved in the DNA damage response (DDR) promoting genomic instability. SOURCE: Frederic Chedin (flchedin@ucdavis.edu) - Chedin UC Davis

Pluto Bioinformatics

GSE130242: Inhibition of protein arginine methylation alters RNA metabolism and DNA damage response providing a new therapeutic strategy in PDAC