Pluto Bioinformatics

GSE115256: Low Cell-Matrix Adhesion Reveals Two Subtypes of Human Pluripotent Stem Cells

Bulk RNA sequencing

The human pluripotent stem cells cultured on Low-adhesion substrates formed two morphologically different subtypes (Monolayer and Domed). The dome-like cells showed higher proliferation capacity and KLF4/5 expression than the monolayer cells. A serum response factor based regulatory double loop was proposed to explain how cell-matrix adhesion mediates the interaction between cell morphology and pluripotency genes SOURCE: Leqian Yu (ylq.urakuken@gmail.com) - Kyoto university