Pluto Bioinformatics

GSE98413: Role of JunB in Th17 cell effector stability [RNA-seq]

Bulk RNA sequencing

Here we identify the activator protein-1 (AP-1) factor JunB as an essential regulator of Th17 cell identity. JunB activates the expression of Th17 lineage-specifying genes, and coordinately represses genes controlling Th1 and Treg fate. Through regulatory analysis, we find that JunB is a core regulator of global transcriptional programs that promote Th17 cell identity and restrict alternative CD4+ T cell potential. SOURCE: Maria Ciofani (maria.ciofani@duke.edu) - Duke University Medical Center