Pluto Bioinformatics

GSE115141: Ongoing classical IL-6 signaling is required to maintain a pathogenic Th17 response in vivo

Bulk RNA sequencing

Th17 precursors from WT and IL6ra-/- mice were co-transferred into Rag1-/- mice to induce colitis. RNA was isolated from CD4+ T cells pre-transfer and from colonic CD4+ T cells 4 weeks post- transfer; ; Another aim is to compare gene expression of WT (IL-6) v WT (HDS) v IL6RaKO (HDS) in vitro polarized Thy1.1+ Th17p cells SOURCE: Min Gao (mgao@uabmc.edu) - University of Alabama at Birmingham