Pluto Bioinformatics

GSE115130: RNAseq of laser captured spinal and oculomotor neurons in post mortem material of ALS patients

Bulk RNA sequencing

Gene expression profiles of specific neuronal populations might explain differential vulnerability to neurodegeneration in the lethal disease amyotrophic lateral sclerosis (ALS). Using laser capture microscopy (LCM) and RNA sequencing (LCM-seq), we demonstrate that the molecular signature of degeneration-resistant oculomotor neurons (OMNs) is distinct from that of vulnerable spinal motor neurons (MNs). SOURCE: Eva Hedlund (eva.hedlund@ki.se) - Hedlund, Biomedicum D7 Karolinska Institutet