Understanding how differentiation, microenvironment, and hormonal milieu influence human breast cell susceptibility to malignant transformation will require the use of physiologically relevant in vitro systems. We developed a 3D culture model that enables the propagation of normal estrogen receptor alpha (ER)+ cells. The purpose of this experiment was to assess ER functionality and compare estrogen-induced transcripts among samples and systems. SOURCE: Paul Yaswen (P_Yaswen@lbl.gov) -  LBNL

Pluto Bioinformatics

GSE115112: Estrogen responsive transcriptome of estrogen receptor positive normal human breast cells in 3D cultures