Pluto Bioinformatics

GSE95072: RNAseq data from Mesenchymal stem cells treated with TCDD or 1-methyl tryptophan

Bulk RNA sequencing

Whole genome RNA-sequencing identified Nrf2, MAPK12 and IL-1a as important downstream targets of 1MT. We further demonstrate 1a1 and 1b1 activation by 1MT in IDO+ MSC following interferon- (IFN) activation, suggestive that 1MT-driven AHR signaling is uncoupled from IDO catalytic function. These observations support a novel paradigm by which AHR-activating compounds like 1MT can be used in cancer immunotherapy to stimulate a pro-inflammatory response, activating the bodys immune system to infiltrate and eradicate tumors. SOURCE: Gregory,K,Tharp (gktharp@emory.edu) - Genomics Core Yerkes National Primate Research Center