Beside their role in conventional immune regulation, macrophages are now recognised as essential regulator of local tissue homeostasis depending on the tissue in which they reside. Using phenotyping, we found that LYVE-1+ macrophages are the major resident macrophage population in murine aorta and adipose tissues under steady state. Furthermore, imaging analysis revealed the exclusive association of adipose tissue LYVE-1+ macrophages with smooth muscle positive large blood vessels. Hence, we hypothesize that LYVE-1+ macrophages sustain large vessel functional homeostasis. The present experiment aims to better characterize resident LYVE-1+ vs LYVE-1- macrophages in aorta and adipose tissues. SOURCE: Daniel Carbajo (daniel_carbajo@immunol.a-star.edu.sg) -  SIgN (A*STAR)

Pluto Bioinformatics

GSE114630: Profiling of murine resident adipose tissue and aortic macrophages according to their expression status of LYVE-1