Pluto Bioinformatics

GSE136339: Whole transcriptome RNA sequencing of human cells after HCV infection (ML-1 thyroid cell line, primary thyrocytes and Huh7.5 hepatocyte cell line)

Bulk RNA sequencing

HCV infection induce thyroid dysfunction by influencing both immune and non immune thyroid-toxic mechanisms. Similar to hepatocytes, HCV infection of thyrocytes had a significant effect on pathways of lipid and glucose metabolic processes (Figures 6A-C). These findings may suggest that HCV infection has a dual effect, inducing pathways that trigger autoimmunity as well as metabolic pathways. SOURCE: Weijia Zhang (weijia.zhang@mssm.edu) - Bioinfomatics Icahn School of Medicine at Mount Sinai