Pluto Bioinformatics

GSE134151: Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimers disease model

Bulk RNA sequencing

This dataset allows for the exploration of microglial function on gene expression in wild-type and the 5xFAD mouse model of Alzheimer's disease, across multiple brain regions. Mice were treated with the selective CSF1R inhibitor PLX5622, which eliminates >95% of microglia in less than 5 days, from 1.5 to 7 months of age. Thus, these data allow the exploration of the effects, and specificity, of 6 months microglial depletion, in both wild-type and 5xFAD mice. SOURCE: Kim Green ( - University of California, Irvine

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