Pluto Bioinformatics

GSE128748: RNA-seq analysis of dolastatin 15 treatment in HCT116 cells

Bulk RNA sequencing

Dolastatin 15 is a known tubulin binding agent and shows remarkable differential cytotoxicity against a panel of colorectal HCT116 isogenic cells. The compound causes anti-vascularization effect in human endothelial cells (HUVEC) in a dose dependent manner. Antiangiogenic effect was further validated in a zebrafish genetic model with activated HIF SOURCE: Tongjun Gu (tgu@ufl.edu) - The University of Florida