Pluto Bioinformatics

GSE61476: FOXG1-dependent dysregulation of GABA/glutamate neuron differentiation in autism spectrum disorders

Bulk RNA sequencing

Autism spectrum disorder (ASD) is a disorder of brain development believed, in most cases, to be of genetic origin. We use induced pluripotent stem cells (iPSCs)-derived 3-dimensional neural cultures (organoids) in patients with ASD and macrocephaly to investigate neurodevelopmental alterations that cause this form of ASD. By using transcriptome analyses, we identified modules of co-expressed genes significantly upregulated in ASD patients compared to non-ASD first-degree family members. SOURCE: Flora VaccarinoVaccarino Yale University