Pluto Bioinformatics

GSE102348: High-Resolution Dissection of Conducive Somatic Cell Reprogramming to Nave Ground State Pluripotency in Mbd3/NuRD and Gatad2a/NuRD Depleted Systems [RNA-Seq]

Bulk RNA sequencing

Reprogramming of somatic cells to induced pluripotent stem cells provoke immense interest both for clinical applications in regenerative medicine, and in understanding the regulation of cell identity. Previous characterization of the molecular events that underlie this process were limited by the low yield and by the stochastic dynamics of this process. Here we present an in-depth mapping of the molecular events that underlie an efficient and successful reprogramming, covering transcriptional, epigenetic and translational changes in a single day resolution. SOURCE: Noa Novershtern (noa.novershtern@weizmann.ac.il) - Weizmann Institute of Science