Pluto Bioinformatics

GSE137456: A non-pharmacological approach in the gut triggers distal metabolic rewiring capable of ameliorating diet-induced metabolic dysfunction

Bulk RNA sequencing

Here we show that Libramed has remarkable, beneficial effects on daily metabolism of an animal model of diet-induced obesity. We decipher the molecular and genomic signatures by which Libramed exerts its effects, and link them to the modifications in the composition of the gut microbiota observed upon its administration. Finally, we describe the mechanism by which such effects are obtained, highlighting the fact that the amelioration of metabolic dysfunction observed upon Libramed administration is profound and of systemic nature, despite being originated by sequestering, therefore non-pharmacological events elicited in the gut lumen. SOURCE: Siwei Chen (siweic@uci.edu) - Pierre Baldi University of California, Irvine