Pluto Bioinformatics

GSE60827: RNA-Seq analysis comparing p53-null versus Np63/;p53-null or Np73/;p53-null thymic lymphoma tumors

Bulk RNA sequencing

We performed an RNA-Seq analysis comparing thymic lymphoma tissues from the p53-null(n=2) and Np63/;p53-/- (n=3) or Np73/;p53-/-(n=3). Mice at 10 weeks of age were injected with either Ad-mCherry or Ad-CRE-mCherry to delete Np63/Np73 in the thymic lmyphomas. We aimed to test by deleting the DNp63/DNp73 in these p53-deficient tumors will mediate tumor regression and analyze the expression profile of the genes SOURCE: Elsa,Renee,Flores (elsaflores@mdanderson.org) - University of Texas MD Anderson Cancer Center