Pluto Bioinformatics
GSE121332: Estrogen receptor beta enhances chemotherapy response of GBM cells by down regulating DNA damage response pathways
Bulk RNA sequencing
We examined the transcriptional changes modulated by estrogen receptor beta (ER) by performing global transcriptome analysis. U87 cells were transduced with lentiviral particles carrying either empty vector or ER-FLAG expression vector and the RNA was isolated and utilized for RNA-seq analysis. Our results demonstrated that ER modulated genes were related to homologous recombination, DNA damage response, ATM signaling and cell cycle pathways. SOURCE: YI ZOU (zou@uthscsa.edu) - UTHSA-GCCRI