This study investigated the biological function of Phc2 by Phc2 knock out mice. Polycomb group (PcG) proteins function as transcriptional repressors of target genes by mainly modulating histone methylation. The canonical Polycomb repressor complex 1 (PRC1), type of PcG proteins, recognizes and binds to H3K27me3 to sustain the transcriptional repression of a target gene. To investigate the function of canonical PRC1, We identified  potential function of Phc2 that is component of  the canonical PRC1 by Phc2 knock out mice. SOURCE: In byung Park Korea University

Pluto Bioinformatics

GSE128705: Transcriptome analysis of bone marrow in Phc2 knock out mice