Pluto Bioinformatics

GSE117713: Transcriptome analysis of murine B cell and CLL samples

Bulk RNA sequencing

Transcriptional profiling revealed that murine VH11 and non-VH11 CLL differed in the upregulation of specific pathways implicated in cell signaling and metabolism. We identified a gene expression signature (including Ccdc88a, Clip3, Zcchc18, Chd3 and Itm2a) that was significantly upregulated in T cell-dependent non-VH11 CLL compared with T cell-independent VH11/Vk14 or mutated IgH.TE CLL. SOURCE: Ralph Stadhouders (stadhoudersralph@gmail.com) - Erasmus Medical Center