Pluto Bioinformatics

GSE136654: KSHV Requires vCyc to Overcome Replicative Senescence in Primary Human Lymphatic Endothelial Cells

Bulk RNA sequencing

We performed high throughput RNA-sequencing on KSHV-infected blood and lymphatic HMVECs at 48hpi as well as WTKSHV- or KSHVDvcyc-infected lymphatic HMVECS at 1wpi to identify differences in gene expression induced by KSHV in these two cell types and gene expression changes that require the KSHV latent gene vcyclin. SOURCE: Terri DiMaio (tdimaio@u.washington.edu) - Lagunoff University of Washington