Pluto Bioinformatics

GSE37646: Distinct STAT5 concentrations uniquely control establishment and differentiation of mammary epithelium during pregnancy

Bulk RNA sequencing

To dissect regulatory processes of cell proliferation and differentiation we generated mouse strains carrying any combination of the four Stat5 alleles, thus expressing STAT5 from 0 to 100%. RNA-Seq analyses revealed that different STAT5 levels activate specific genetic programs linked to cell proliferation and differentiation. SOURCE: Keunsoo Kang (kangk2@niddk.nih.gov) - LGP NIH