Pluto Bioinformatics

GSE113947: RNA-Seq of isogenic human iPS cell-derived cardiomyocytes with RBM20 mutations created by genome editing

Bulk RNA sequencing

RBM20 heterozygous (Het) and homozygous (Homo) R636S and homozygous 8-bp deletion (which causes nonsense-mediated decay) mutations were created by genome editing in an iPS cell line generated from a healthy male patient. Those cells were differentiated into cardiomyocytes by modulating the WNT signaling pathway, and then are subjected to the lactate purification method. SOURCE: Nathan Salomonis (nathan.salomonis@cchmc.org) - Nathan Salomonis Cincinnati Children's Hospital