Pluto Bioinformatics

GSE133933: Effect of fibulin-3 knockdown on malignant mesothelioma cells

Bulk RNA sequencing

Whole transcriptome comparison of mesothelioma cells transfected with control vs Fibulin-3 (EFEMP1) siRNAs. Mesothelioma cells H-226 (ATCC) and H-2595 (Harvey Pass, New York University) were transfected with two fibulin-3 or control siRNAs and collected 48h after transfection. Gene expression was quantified by RNAseq using standard procedures. The results suggest that downregulation of fibulin-3 negatively affects a PI3K/AKT-dependent gene signature involved in cell growth, adhesion, and association with the extracellular matrix. SOURCE: Mariano,S,Viapiano ( - Brain Tumor Laboratory SUNY Upstate Medical University

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