Pluto Bioinformatics

GSE136158: CSF1R inhibitor-mediated microglial depletion prevents reductions in striatal volume, extracellular matrix alterations, and perineuronal net loss in a mouse model of Huntingtons disease

Bulk RNA sequencing

This dataset allows for the exploration of gene expression of microdissected striatum from 11 week old wild-type and the R6/2 mouse model of Huntington's disease, in the presence or absence of microglia. Microglia were depleted via dietary administration of the CSF1R inhibitor PLX3397 from 6 to 11 weeks of age. SOURCE: Kim Green (kngreen@uci.edu) - University of California, Irvine