Pluto Bioinformatics

GSE85089: Integrator orchestrates RAS/ERK1/2 signaling transcriptional programs

Bulk RNA sequencing

We investigated the occupancy of RNA PolII and INTS11 during the stimulation of EGF and compared with drug treated condition using inhibitors against MAPK pathway and Integrator. Additionally, we examined transcription by sequencing the chromatin-bound fraction of RNA. SOURCE: Jingyin Yue (jxy154@med.miami.edu) - Shiekhattar, Ramin University of Miami