Pluto Bioinformatics

GSE148731: Analyzing the impact of Mycobacterium tuberculosis infection on primary human macrophages

Bulk RNA sequencing

The success of Mycobacterium tuberculosis (Mtb) as pathogen is tightly linked to its ability to recalibrate host metabolic processes in infected host macrophages. Correspondingly, analysis of RNA-sequencing datasets showed altered gene expression of key metabolic enzymes involved in NAD+, creatine, glucose and glutamine metabolism (e.g NAMPT, IDO1, SLC6A8, CKB, HK2) in Mtb-infected M2 macrophages. SOURCE: Herman,Pieter,Spaink (h.p.spaink@biology.leidenuniv.nl) - Molecular Cell Biology Leiden University